JOURNAL OF CHILEAN CHEMICAL SOCIETY

Vol 64 No 4 (2019): Journal of the Chilean Chemical Society
Original Research Papers

SIMULTANEOUS QUANTITATION OF MOXIFLOXACIN AND STATINS IN API BY RP-HPLC

Safila Naveed
Faculty of pharmacy, Jinnah university for Women Karachi,
Bio
Published December 17, 2019
Keywords
  • Moxifloxacin,
  • statins,
  • HPLC,
  • method validation

Abstract

Moxifloxacin belongs to broad spectrum flouroquinolone class and having antimicrobial activity. A rapid, cheap, reliable and accurate method has been developed and validated for the simultaneous analysis of Moxifloxacin with statin in active and in dosage formulation. Chromatographic separation was carried out using Purospher star C18 (5 µm, 25 × 0.46 cm) column at room temperature (25± 2 oC) with flow rate of 1 ml /min,  detector was set at 250nm and mobile Phase was 95:5 v/v methanol: water. The correlation coefficient of both drugs was found to be > 0.990 and 0.999. Small sample is taken for limit of quantification.

 

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