JOURNAL OF CHILEAN CHEMICAL SOCIETY

Vol 61 No 3 (2016): Journal of the Chilean Chemical Society
Original Research Papers

SYNTHESIS AND ANTIFUNGAL ACTIVITY OF DIARYL HYDRAZONES FROM 2,4 DINITROPHENYLHYDRAZINE

Sergio Ortiz
Departamento de Química, Universidad Católica del Norte
Ronald Nelson
Departamento de Química, Universidad Católica del Norte
Víctor Kesternich
Departamento de Química, Universidad Católica del Norte
Marcia Pérez-Fehrmann
Departamento de Química, Universidad Católica del Norte
Philippe Christen
School of Pharmaceutical Sciences, University of Geneva, University of Lausanne
Laurence Marcourt
School of Pharmaceutical Sciences, University of Geneva, University of Lausanne
Published September 10, 2016
Keywords
  • Antifungal Activity,
  • Diarylhydrazones,
  • Schiff bases
How to Cite
Ortiz, S., Nelson, R., Kesternich, V., Pérez-Fehrmann, M., Christen, P., & Marcourt, L. (2016). SYNTHESIS AND ANTIFUNGAL ACTIVITY OF DIARYL HYDRAZONES FROM 2,4 DINITROPHENYLHYDRAZINE. Journal of the Chilean Chemical Society, 61(3). Retrieved from https://jcchems.com/index.php/JCCHEMS/article/view/83

Abstract

A new series of diarylhydrazones derived from 2,4-dinitrophenylhydrazine were synthesized via condensation with aromatic aldehydes whose structures have been determined by mass spectrometry, infrared spectroscopy, and nuclear magnetic resonance spectra. Yields were 50–99%. All compounds were screened in vitro for their antifungal activity. Preliminary results indicated that compounds 3g and 3h exhibited promising antifungal potency. Understanding of the structure of these compounds establishes a preliminary structure-activity relationship to form the basis of further investigation. 

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