- Antifungal Activity,
- Diarylhydrazones,
- Schiff bases
Copyright (c) 2017 Sergio Ortiz, Ronald Nelson, Víctor Kesternich, Marcia Pérez-Fehrmann, Philippe Christen, Laurence Marcourt
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
Abstract
A new series of diarylhydrazones derived from 2,4-dinitrophenylhydrazine were synthesized via condensation with aromatic aldehydes whose structures have been determined by mass spectrometry, infrared spectroscopy, and nuclear magnetic resonance spectra. Yields were 50–99%. All compounds were screened in vitro for their antifungal activity. Preliminary results indicated that compounds 3g and 3h exhibited promising antifungal potency. Understanding of the structure of these compounds establishes a preliminary structure-activity relationship to form the basis of further investigation.
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