A NOVEL NORMULINANE ISOLATED FROM Azorella compacta AND ASSESSMENT OF ITS ANTIBACTERIAL ACTIVITY
- Azorella compacta,
- diterpenes,
- normulinane,
- yareta
Copyright (c) 2018 Journal of the Chilean Chemical Society
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
Abstract
Phytochemical analysis of Azorella compacta resulted in the isolation of six known diterpenes and one unknown norditerpene using chromatographic methods. The structure of this new compound was established by spectroscopic analysis. The bioactivity of the new compound was assessed against six oral bacteria using a drop test method. A high level of growth inhibition was observed against F. nucleatum and P. gingivalis; however, other species such as V. parvula and A. actinomycetemcomitans were not affected.
References
- J. R. Hanson Nat. Prod. Rep., 21, 312 (2004).
- L. Quesada, C. Areche, L. Astudillo, M. Gutierrez, B. Sepulveda, and A. San-Martín, Nat. Prod. Commun., 7, 1187 (2012).
- J. Borquez, A. Ardiles, L. A. Loyola, L. M. Pena-Rodriguez, G. M. Molina- Salinas, J. Vallejos, I. G. Collado, and M. J. Simirgiotis Molecules, 19, 3898 (2014).
- A. San-Martín, V. Donoso, S. Leiva, M. Bacho, S. Nunez, M. Gutierrez, J. Rovirosa, N. Bailon-Moscoso, S. C. Camacho, O. M. Aviles, and M. E. Cazar Curr. Top. Med. Chem., 15, 1743 (2015).
- L. A. Loyola, J. Borquez, G. Morales, J. Araya, I. Neira, H. Sagua, and A. San-Martín. Bol. Soc. Chil. Quim., 46, 9 (2001).
- C. Areche, P. Cejas, P. Thomas, A. San-Martín, L. Astudillo, M. Gutiérrez, and L. A. Loyola Quim. Nova, 32, 2023 (2009).
- L. Astudillo, M. Gutierrez, L. Quesada, A. San-Martín, L. Espinoza, and P. Penailillo Nat. Prod. Commun., 9, 9 (2014).
- M. A. Munoz, A. San-Martín, and P. Joseph-Nathan Nat. Prod. Commun., 10, 1343 (2015).
- K. P. Reber, J. Xu, and C. A. Guerrero J. Org. Chem., 80, 2397 (2015).
- C. B. Colloca, D. B. Pappano, D. A. Bustos, V. E. Sosa, R. F. Baggio, M. T. Garland, and R. R. Gil Phytochem., 65, 2085 (2004).
- S. Lopez, B. Lima, M. B. Aguero, M. L. Lopez, M. Hadad, J. Zygadlo, D. Caballero, R. Stariolo, E. Suero, G. Feresin and A. Tapia, Arabic Journal of Chemistry, 11, 2, 187 (2014).
- F. Salgado, C. Areche, B. Sepulveda, M. J. Simirgiotis, F. Caceres, C. Quispe, L. Quispe, and T. Cano Pharmacogn. Mag., 10, 543 (2014).
- L. A. Loyola, G. Morales, B. Rodriguez, J. Jimenezbarbero, S. Pedreros, M. C. Delatorre, and A. Perales J. Nat. Prod., 54, 1404 (1991).
- L. A. Loyola, J. Borquez, G. Morales, A. San-Martín, V. Manriquez, and O. Wittke Tetrahedron, 54, 15533 (1998).
- G. A. Wachter, G. Matooq, J. J. Hoffmann, W. M. Maiese, M. P. Singh, G. Montenegro, and B. N. Timmermann J. Nat. Prod., 62, 1319 (1999).
- J. Borquez, L. A. Loyola, G. Morales, A. San-Martín, R. Roldan, N. Marquez, and E. Munoz Phytother. Res., 21, 1082 (2007).
- G. M. Molina-Salinas, J. Borquez, A. Ardiles, S. Said-Fernandez, L. A. Loyola, A. Yam-Puc, P. Becerril-Montes, F. Escalante-Erosa, A. San- Martín, I. Gonzalez-Collado, and L. M. Pena-Rodríguez Phytochem. Rev., 9, 271 (2010).
- A. F. Olea, H. Carrasco, L. Espinoza, and B. Acevedo J. Chil. Chem. Soc., 59, 2451 (2014).
- L. Taborga, K. Diaz, A. F. Olea, P. Reyes-Bravo, M. E. Flores, H. Pena- Cortes, and L. Espinoza J. Agric. Food Chem., 63, 6890 (2015).
- S. Bonjar J. Ethnopharmacol., 94, 301 (2004).
- A. Souza, C. Martins, M. Souza, N. Furtado, V. Heleno, J. de Sousa, E. Rocha, J. Bastos, W. Cunha, R. Veneziani, S. Ambrósio, Phytotherapy Research, 25, 2, 215 (2011).
- T. Suman, V. Anuradha, R. Devi, Journal of Pure and Applied Microbiology, 4, 1, 231 (2010).
- J. Rovirosa, V. Blanc, R. Leon, A. San-Martín, J. Chil. Chem. Soc., 58, 4, 2025 (2013).