JOURNAL OF CHILEAN CHEMICAL SOCIETY

Vol 63 No 1 (2018): Journal of the Chilean Chemical Society
Original Research Papers

PRELIMINARY PHYTOCHEMICAL STUDY OF THE ECUADORIAN PLANT CROTON ELEGANS KUNTH (EUPHORBIACEAE)

Claudia Herrera
Departamento de Química y Ciencias Exactas, Universidad Técnica Particular de Loja (UTPL), Loja
Yanely Pérez
Departamento de Química y Ciencias Exactas, Universidad Técnica Particular de Loja (UTPL), Loja
Vladimir Morocho
Departamento de Química y Ciencias Exactas, Universidad Técnica Particular de Loja (UTPL), Loja
Chabaco Armijos
Departamento de Química y Ciencias Exactas, Universidad Técnica Particular de Loja (UTPL), Loja
Omar Malagón
Departamento de Química y Ciencias Exactas, Universidad Técnica Particular de Loja (UTPL), Loja
Beatriz Brito
Instituto Nacional de Investigaciones Agropecuarias (INIAP), Quito
Marcelo Tacán
Instituto Nacional de Investigaciones Agropecuarias (INIAP), Quito
Luis Cartuche
Departamento de Química y Ciencias Exactas, Universidad Técnica Particular de Loja (UTPL), Loja
Gianluca Gilardoni
Departamento de Química y Ciencias Exactas, Universidad Técnica Particular de Loja (UTPL), Loja Prometeo Project Researcher, SENESCYT, Quito
Published April 25, 2018
Keywords
  • Croton elegans,
  • alkaloid,
  • secondary metabolite,
  • Ecuador,
  • NMR,
  • mosquera,
  • friedelin,
  • cycloeucalenol,
  • ( )-pallidine,
  • ( )-O-methylpallidine
  • ...More
    Less

Abstract

The species Croton elegans Kunth, belonging to the family Euphorbiaceae and known with the common name “mosquera”, is a native medicinal plant of Ecuador. Due to its medical applications, we are interested in secondary metabolite composition. After extraction with hexane and preparation of the alkaloid extract, preparative chromatographic fractionation in both normal and direct phase was performed. 1H NMR, 13C NMR, HSQC and HMBC experiments, together with polarimetric measurements, were conducted in order to characterize the purified compunds. Two triterpene metabolites (friedelin and cycloeucalenol) and two morphinan alkaloids ((+)-pallidine and (+)-O-methylpallidine) were obtained in a pure form. This work represents the first report on the phytochemistry of C. elegans and probably the second publication on the natural (+)-pallidine alkaloid.

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