JOURNAL OF CHILEAN CHEMICAL SOCIETY

Vol 62 No 4 (2017): Journal of the Chilean Chemical Society
Original Research Papers

pH DEPENDENT DRUG DELIVERY BASED ON SILICA XEROGEL

Aécio B. P. de Vasconcelos
Departamento de Química, Universidade Federal Rural de Pernambuco
Wagner E. Silva
Departamento de Química, Universidade Federal Rural de Pernambuco
Mônica F. Belian
Departamento de Química, Universidade Federal Rural de Pernambuco
Published February 9, 2018
Keywords
  • silica xerogel,
  • pH-dependent release,
  • ibuprofen
How to Cite
de Vasconcelos, A. B. P., Silva, W. E., & Belian, M. F. (2018). pH DEPENDENT DRUG DELIVERY BASED ON SILICA XEROGEL. Journal of the Chilean Chemical Society, 62(4). Retrieved from https://jcchems.com/index.php/JCCHEMS/article/view/461

Abstract

In this work, a matrix based on silica xerogel, synthesized from TEOS, water, ibuprofen (as template) and acetic acid at room temperature, was used for ibuprofen (IBF) incorporation, aiming to create a drug delivery system capable of releasing this compound under a basic pH condition (considering desirable and optimal release in the intestines). The IBF release was checked at different pH values (ranging from 2 to 8), using appropriate buffered solutions. After observing the IBF release performance from the silica xerogel and its dependence on the pH, the same matrix containing IBF was submitted to a novel assay, using only a pH 7 buffered solution as the best way to check the chronological release. This was carried out at 1, 2, 5 and 10 minutes to determine aliquot removal, as well as IBF concentration at each elapsed period.

References

  1. L. Zhou, J. H. Liu, J. Zhang, S. H. Wei, Y. Y. Feng, J. H. Zhou, B. Y. Yu, J. Shen, Inter. J. of Pharm. 386, 131, (2010).
  2. M. Vallet-Regi, A. Ramila, R. P. del Real, J. Perez-Pariente, Chem. Mater. 13, 308, (2001).
  3. J. Andersson, J. Rosenholm, S. Areva, M. Linden, Chem. Mat. 21, 4160, (2004).
  4. D. Jin, J. H. Lee, M. L. Seo, J. Jaworski, J. H. Jung, New J. Chem. 36, 1616, (2012).
  5. C. H. Lee, L. W. Lo, C. Y. Mou, C. S. Yang, Adv. Funct. Mater. 18, 3283, (2008).
  6. B. Wang, C. Xu, J. Xie, Z. Yang, S. Sun, J. Am. Chem. Soc. 130, 14436, (2008).
  7. C. Gao, H. Zheng, L. Xing, M. Shu, S. Che, Chem. Mater. 22, 5437, (2010).
  8. H. Zheng, Y. Wang, S. Che, J. Phys. Chem. C 115, 16803, (2011).
  9. J. Lu, Z. Li, J. I. Zink, F. Tamanoi, Nanomedicine: Nanotech., Biol. and Med. 8, 212, 2, (2012).
  10. B. Chen, G. Quan, Z. Wang, J. Chen, L. Wu, Y. Xu, G. Li, C. Wu, Powder Techn. 240, 48, (2013).
  11. Q. He, Y. Gao, L. Zhang, Z. Zhang, F. Gao, X. Ji, Y. Li, J. Shi, Biomat. 32, 7711, 30, (2011).
  12. Y. Liu, H. Miyoshi, M. Nakamura, Colloids and Surf. B: Biointer. 58, 180, 2, (2007).
  13. A. Sousa, K. C. Souza, E. M. B. Sousa, Acta Biomat. 4, 671, 3 (2008).
  14. U. Guenther, I. Smirnova, R. H. H. Neubert, Eur. J. of Pharm. and Biopharm. 69, 935, 3, (2008).
  15. Q. He, J. Shi, J. Chen, M. Zhu, L. Zhang, Biomat. 31, 3335, 12, (2010).
  16. L. Jia, J. Shen, Z. Li, D. Zhang, Q. Zhang, C. Duan, G. Liu, D. Zheng, Y. Liu, X. Tian, Inter. J. of Pharm. 439, 81, 1–2, (2012).
  17. F. Qu, G. Zhu, H. Lin, W. Zhang, J. Sun, S. Li, S. Qiu, J. of Solid State Chem. 179, 2027, (2006).
  18. C. A. Aerts, E. Verraedt, A. Depla, L. Follens, L. Froyen, J. V. Humbeeck, P. Augustijns, G. V. Mooter, R. Mellaerts, J. A. Martens, Inter. J. of Pharm. 397, 84, 1-2, (2010).
  19. N. H. N. Kamarudin, A. A. Jalil, S. Triwahyono, N. F. M. Salleh, A. H. Karim, R. R. Mukti, B. H. Hameed, A. Ahmad, Micro. and Mesop. Mat. 180, 235, (2013).
  20. X. Du, J. He, J. of Colloid and Inter. Science 345, 269, (2010).
  21. Y.-F. Zhu, J.-L. Shi, Y.-S. Li, H.-R. Chen, W.-H. Shen, X.-P. Dong, Micro. and Mesop. Mat. 85, 75, (2005).
  22. S. Brunauer, P. Emmett, E. Teller, JACS 60, 309, (1938).
  23. E. P. Barrett, L. J. Joyner, P. P. Halend, I. Computations from nitrogen isotherms, I-Computations from nitrogen isotherms 72, 340, (1951).
  24. D. Pérez-Quintanilla, I. Hierro, I. Sierra, Micro. and Mesop. Mat. 89, 58, (2006a).
  25. V. Meynen, P. Cool, E. F. Vansant, Micro. and Mesop. Mat. 125, 170, (2009).
  26. K. S. W. Sing, International Union of Pure and Applied Chemistry 54, 2201, (1982).

Copyright @2019 | Designed by: Open Journal Systems Chile Logo Open Journal Systems Chile Support OJS, training, DOI, Indexing, Hosting OJS

Code under GNU license: OJS PKP