Vol 62 No 4 (2017): Journal of the Chilean Chemical Society
Original Research Papers


Aécio B. P. de Vasconcelos
Departamento de Química, Universidade Federal Rural de Pernambuco
Wagner E. Silva
Departamento de Química, Universidade Federal Rural de Pernambuco
Mônica F. Belian
Departamento de Química, Universidade Federal Rural de Pernambuco
Published February 9, 2018
  • silica xerogel,
  • pH-dependent release,
  • ibuprofen
How to Cite
de Vasconcelos, A. B. P., Silva, W. E., & Belian, M. F. (2018). pH DEPENDENT DRUG DELIVERY BASED ON SILICA XEROGEL. Journal of the Chilean Chemical Society, 62(4). Retrieved from


In this work, a matrix based on silica xerogel, synthesized from TEOS, water, ibuprofen (as template) and acetic acid at room temperature, was used for ibuprofen (IBF) incorporation, aiming to create a drug delivery system capable of releasing this compound under a basic pH condition (considering desirable and optimal release in the intestines). The IBF release was checked at different pH values (ranging from 2 to 8), using appropriate buffered solutions. After observing the IBF release performance from the silica xerogel and its dependence on the pH, the same matrix containing IBF was submitted to a novel assay, using only a pH 7 buffered solution as the best way to check the chronological release. This was carried out at 1, 2, 5 and 10 minutes to determine aliquot removal, as well as IBF concentration at each elapsed period.


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