JOURNAL OF CHILEAN CHEMICAL SOCIETY

Vol 61 No 1 (2016): Journal of the Chilean Chemical Society
Original Research Papers

SYNTHESIS AND ANTIMICROBIAL EVALUATION OF SOME NEW ASYMMETRICALLY SUBSTITUTED 4-ARYL- 2,6-DI(COUMARINYL) PYRIDINES

Yogita L. Chovatiya
Department of Chemistry, Sardar Patel University, Vallabh Vidyanagar 388120, Gujarat
Kaushik N. Kundaliya
Department of Chemistry, Sardar Patel University, Vallabh Vidyanagar 388120, Gujarat
Rakesh R. Giri
Department of Chemistry, Sardar Patel University, Vallabh Vidyanagar 388120, Gujarat
Dinker I. Brahmbhatt
Department of Chemistry, Sardar Patel University, Vallabh Vidyanagar 388120, Gujarat
Published December 10, 2015
Keywords
  • Dicoumarinyl pyridines,
  • Krohnke’s reaction,
  • Antimicrobial activity,
  • Broth dilution method
How to Cite
Chovatiya, Y. L., Kundaliya, K. N., Giri, R. R., & Brahmbhatt, D. I. (2015). SYNTHESIS AND ANTIMICROBIAL EVALUATION OF SOME NEW ASYMMETRICALLY SUBSTITUTED 4-ARYL- 2,6-DI(COUMARINYL) PYRIDINES. Journal of the Chilean Chemical Society, 61(1). Retrieved from https://jcchems.com/index.php/JCCHEMS/article/view/45

Abstract

In the present work the synthesis of various 4-aryl-2-(coumarin-3-yl)-6-(4-methyl-3-phenyl coumarin-6-yl)pyridines (6a-i) and 4-aryl-2-(coumarin-3-yl)- 6-(4-methyl-7-methoxy coumarin-8-yl)pyridines (7a-i) have been carried out by reacting 1-[2(H)-1-benzopyran-3-yl]-3-aryl-prop-2-en-1-ones (coumarinoyl chalcones) (3a-f) with appropriate coumarinoyl methyl pyridinium bromide salt 4 and 5 respectively. The target compounds were characterized by the IR, 1H-NMR, 13C-APT and mass spectral analysis. Preliminary examination of target compounds as antimicrobial agents has been carried out using Broth dilution method.

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