JOURNAL OF CHILEAN CHEMICAL SOCIETY

Vol 62 No 3 (2017): Journal of the Chilean Chemical Society
Original Research Papers

A REVIEW OF RAMAN, SURFACE-ENHANCED RAMAN SCATTERING (SERS) AND RELATED SPECTROSCOPIC TECHNIQUES APPLIED TO BIOMOLECULES IN BIOMATERIALS

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  • Freddy Celis,
  • Macarena Garcia,
  • Guillermo Diaz-Fleming,
  • Marcelo Campos-Vallette
Freddy Celis
Laboratorio de Espectroscopía Vibracional Aplicada, Departamento de Química y Centro de Estudios Avanzados (CEA), Universidad de Playa Ancha Laboratorio de Espectroscopía Vibracional, Departamento de Química, Universidad de Chile
Macarena Garcia
Laboratorio de Polímeros Conductores, Departamento de Química de los Materiales, Facultad de Química y Biología, Universidad de Santiago de Chile
Guillermo Diaz-Fleming
Laboratorio de Espectroscopía Atómica y Molecular, CESPAM, Departamento de Química, Universidad de Playa Ancha
Marcelo Campos-Vallette
Laboratorio de Espectroscopía Vibracional, Departamento de Química, Universidad de Chile
Published September 2, 2017
Keywords
  • Raman,
  • SERS,
  • Biomolecules,
  • Biomaterials,
  • Nanoparticles
How to Cite
Celis, F., Garcia, M., Diaz-Fleming, G., & Campos-Vallette, M. (2017). A REVIEW OF RAMAN, SURFACE-ENHANCED RAMAN SCATTERING (SERS) AND RELATED SPECTROSCOPIC TECHNIQUES APPLIED TO BIOMOLECULES IN BIOMATERIALS. Journal of the Chilean Chemical Society, 62(3). Retrieved from https://jcchems.com/index.php/JCCHEMS/article/view/324

Copyright (c) 2017 Journal of the Chilean Chemical Society

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Abstract

The development of new biomaterials has gained increasing attention in the last decade. One of the most important aspects in the development of these new materials is to understand the chemical cues presents in the native niche. Among all the techniques currently available for measuring those interactions, Raman spectroscopy offers a unique and non-invasive tool for exploring the behavior of the components within a given biomaterial and their surrounding microenvironment. This technique exploits the unique molecular vibrational fingerprints for pinpointing those interactions. The vibrational response can be improved to the single molecule level, in the presence of metal nanoparticles (NPs) with plasmonic properties (silver, gold and copper) in the so-called Surface- Enhanced Raman Scattering (SERS), which can be used for in-situ measurements. Another technique recently developed is the Shell-Isolated Nanoparticle- Enhanced Raman Spectroscopy (SHINERS), which overcomes signal contamination from chemical interactions between biomolecules and the metal surface; it does this by coating the metal surface with an inert layer of alumina or silica. In the present contribution, the role and the applications of Raman, SERS and related spectroscopic techniques in the study of biomolecules in biomaterials are reviewed and discussed.

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References

  1. Raman, C.; Krishnan, K. Nature 1928, 121 (3048), 501.
  2. McCreery, R. Raman Spectroscopy for Chemical Analysis; Sons, J. W. &, Ed.; New York, 2000.
  3. Jeanmaire, D. L.; Van Duyne, R. P. Van Duyne, R. P. J. Electroanal. Chem. 1977, 84, 1.
  4. Fleischmann, M.; Hendra, P.; McQuillan, A. Chem. Phys. Lett. 1974, 26 (2), 2.
  5. Garrido, C.; Weiss-López, B. E.; Campos Vallette, M. M. Spectrosc. Lett. 2016, 49, 11.
  6. Stamplecoskie, K. G.; Scaiano, J. C.; Tiwari, V. S.; Anis, H. J. Phys. Chem. C 2011, 115, 1403.
  7. Garcia-Leis, A.; Garcia-Ramos, J. V.; Sanchez-Cortes, S. J. Phys. Chem. C 2013, 117 (15), 7791.
  9. Leopold, N.; Lendl, B. J. Phys. Chem. B 2003, 107 (24), 5723.
  10. Turkevich, J.; Cooper, P.; Hillier, J. Discuss. Faraday Soc. 1951, 11 (c), 55.
  11. Lee, P. C.; Meisel, D. J.Phys.Chem. 1982, 86 (17), 3391.
  12. Alarcon, E. I.; Griffith, M.; Udekwu, K. Silver Nanoparticle Applications: In the fabrication and design of medical and biosensig devices; Alarcon, E. I., Griffith, M., Udekwu, K. I., Eds.; Engineering Materials; Springer International Publishing: Cham, 2015.
  13. Botta, O.; Bada, J.; Gomez-Elvira, J.; Javaux, E.; Selsis, F.; Summons, R. Strategies of life; Springer Science+Business Media: Pilbara, 2008; Vol. November.
  14. Wei, J.; Wang, A.; Lambert, J. L.; Wettergreen, D.; Cabrol, N.; Warren- Rhodes, K.; Zacny, K. J. Raman Spectrosc. 2015, 46 (10), 810.
  15. Diaz Fleming, G.; Martinez-Ortiz, U.; Varas-Aquin, N. Int. J. Chem. Pharm. Sci. 2015, 3 (5), 1665.
  16. Diaz Fleming, G.; Martinez Ortiz, U. J. Spectrosc. Dyn. 2012, 2 (12), 1.
  17. Diaz Fleming, G.; Koch, R.; Muñoz Perez, J.; Llanos Cabrera, J. Vib. Spectrosc. 2015, 80, 70.
  18. Diaz-Fleming, G.; Célis, F.; Fredes, C.; Campos-Vallette, M.; Aliaga, A. E.; Koch, R. J. Raman Spectrosc. 2010, 41 (2), 160.
  19. Cînta Pînzaru, S.; Pavel, I.; Leopold, N.; Kiefer, W. J. Raman Spectrosc. 2004, 35 (5), 338.
  20. Diaz Fleming, G.; Célis, F.; Campos-Vallette, M.; Aliaga, A. E.; Escobar, M.; Koch, R. J. Raman Spectrosc. 2011, 42 (7), 1497.
  21. Pasteris, J. D.; Wopenka, B.; Freeman, J. J.; Brewer, P. G.; White, S. N.; Peltzer, E. T.; Malby, G. E. Appl. Spectrosc. 2004, 58 (7), 195A.
  22. Fleming, G. D.; Celis, F.; Aracena, A.; Campos-Vallette, M.; Aliaga, A. E.; Koch, R. Spectrochim. Acta - Part A Mol. Biomol. Spectrosc. 2012, 89, 222.
  23. Diaz Fleming, G.; Martinez, U.; Guerra, J. J. Spectrosc. Dyn. 2014, 4 (16), 1.
  24. Diaz Fleming, G.; Villagrán, J.; Koch, R. Spectrochim. Acta Part A Mol. Biomol. Spectrosc. 2013, 114, 120.
  25. Doty, K. C.; Muro, C. K.; Bueno, J.; Halámková, L.; Lednev, I. K. J. Raman Spectrosc. 2015, No. November 2015, 39.
  26. Committee, A. M. Anal. Methods 2015, 7 (12), 4844.
  27. Chiao, M.; Chiao, J. Biomaterials for MEMS, 1st ed.; Chiao, M., Chiao, J. C., Eds.; Pan Stanford: Singapure, 2012; Vol. 33.
  28. Ducheyne, P. In Comprehensive Biomaterials II; Ducheyne, P., Grainger, D. B., Healy, K. E., Hutmacher, D. W., Kirkpatrick, C. J., Eds.; Elsevier: Oxford, 2017; p 2017.
  29. Koburger, S.; Bannerman, A.; Grover, L. M.; Müller, F. A.; Bowen, J.; Paxton, J. Z. Biomater. Sci. 2014, 2 (1), 41.
  30. Wu, Y.; Dong, Y.; Jiang, J.; Li, H.; Zhu, T.; Chen, S. Sci. Rep. 2017, 7 (12), 38706.
  31. KUMAR, G. V. P. Bull. Mater. Sci. 2011, 34 (3), 417.
  32. Shashni, B.; Horiguchi, Y.; Kurosu, K.; Furusho, H.; Nagasaki, Y. Biomaterials 2017, 134, 143.
  33. Tathe, A.; Ghodke, M.; Nikalje, A. P. Int. J. Pharm. Sci. 2010, 2 (4), 19.
  34. Misch, C. Contemporary implant dentistry; Mosby-Wolfe: London, 2007.
  35. Williams, D. F. Williams Dictionary of Biomaterials, 1st ed.; Liverpool University Press, 1999.
  36. Ratner, B.; Hoffman, A.; Schoen, F.; Lemons, J. Biomaterials science: An introduction to materials in medicine; Academic Press: Oxford, 2013.
  37. Patel, N. R.; Gohil, P. P. Int. J. Emerg. Technol. Adv. Eng. 2012, 2 (4), 91.
  38. Ifkovits, J. L.; Burdick, J. A. Tissue Eng. 2007, 13 (10), 2369.
  39. Bhullar, S. K.; Lala, N. L.; Ramkrishna, S. Rev. Adv. Mater. Sci. 2015, 40 (3), 303.
  40. Wang, H.; Xu, M.; Zhang, W.; Kwok, D. T. K.; Jiang, J.; Wu, Z.; Chu, P. K. Biomaterials 2010, 31 (32), 8181.
  41. Saber-Samandari, S.; Gross, K. A. Biomaterials 2010, 31 (25), 6386.
  42. Ku, S. H.; Park, C. B. Biomaterials 2010, 31 (36), 9431.
  43. Lopez-Heredia, M. A.; Sohier, J.; Gaillard, C.; Quillard, S.; Dorget, M.; Layrolle, P. Biomaterials 2008, 29 (17), 2608.
  44. Notingher, I.; Verrier, S.; Romanska, H.; Bishop, A. E.; Polak, J. M.; Hench, L. L. Spectroscopy 2002, 16 (2), 43.
  46. Notingher, I.; Hench, L. L. Expert Rev. Med. Devices 2006, 3 (2), 215.
  47. Bandyopadhyay, A.; Bose, S. Characterization of Biomaterials; Elsevier Inc.: Oxford, 2013.
  48. Hench, L. L.; Thompson, I. J. R. Soc. Interface 2010, 7 (May), S379.
  49. Born, R.; Scharnweber, D.; Rößler, S.; Stölzel, M.; Thieme, M.; Wolf, C.; Worch, H. Fresenius. J. Anal. Chem. 1998, 361 (6–7), 697.
  50. Koening, J. Microscopic imaging of polymers; American Chemical Society: Washington, DC, 1998.
  51. Penel, G.; Delfosse, C.; Descamps, M.; Leroy, G. Bone 2005, 36 (5), 893.
  52. Pezzotti, G. Anal. Bioanal. Chem. 2005, 381 (3), 577.
  53. Tarnowski, C. P.; Stewart, S.; Holder, K.; Campbell-Clark, L.; Thoma, R. J.; Adams, A. K.; Moore, M.; Morris, M. J. Biomed. Opt. 2003, 8 (2), 179.
  54. Hagan, C. P.; Orr, J. F.; Mitchell, C. A.; Dunne, N. J. J. Mater. Sci. Mater. Med. 2009, 20 (12), 2427.
  55. Lawson, E. E.; Barry, B. W.; Williams, A. C.; Edwards, H. G. M. J. Raman Spectrosc. 1997, 28, 111.
  56. Rehman, I.; Smith, R.; Hench, L. L.; Bonfield, W. J. Biomed. Mater. Res. 1995, 29, 1287.
  57. Smith, R.; Rehman, I. J. Mater. Sci. Mater. Med. 1994, 5 (9–10), 775.
  58. Harrington, M. J.; Wasko, S. S.; Masic, A.; Fischer, F. D.; Gupta, H. S.; Fratzl, P. J. R. Soc. Interface 2012, 9 (76), 2911.
  60. Schenk, A. S.; Zlotnikov, I.; Pokroy, B.; Gierlinger, N.; Masic, A.; Zaslansky, P.; Fitch, A. N.; Paris, O.; Metzger, T. H.; Cölfen, H.; Fratzl, P.; Aichmayer, B. Adv. Funct. Mater. 2012, 22 (22), 4668.
  61. Bratashov, D. N.; Masic, A.; Yashchenok, A. M.; Bedard, M. F.; Inozemtseva, O. A.; Gorin, D. A.; Basova, T.; Sievers, T. K.; Sukhorukov, G. B.; Winterhalter, M.; Möhwald, H.; Skirtach, A. G. J. Raman Spectrosc. 2011, 42 (10), 1901.
  62. Lee, K.; Wagermaier, W.; Masic, A.; Kommareddy, K. P.; Bennet, M.; Manjubala, I.; Lee, S.; Park, S. B.; Cölfen, H.; Fratzl, P. Nat. Commun. 2012, 3, 725.
  63. Yashchenok, A.; Masic, A.; Gorin, D.; Shim, B. S.; Kotov, N. A.; Fratzl, P.; Möhwald, H.; Skirtach, A. Small 2013, 9 (3), 351.
  64. Gierlinger, N.; Luss, S.; Konig, C.; Konnerth, J.; Eder, M.; Fratzl, P. J. Exp. Bot. 2010, 61 (2), 587.
  65. Masic, A.; Bertinetti, L.; Schuetz, R.; Galvis, L.; Timofeeva, N.; Dunlop, J. W. C.; Seto, J.; Hartmann, M. A.; Fratzl, P. Biomacromolecules 2011, 12 (11), 3989.
  66. Bennet, M.; Akiva, A.; Faivre, D.; Malkinson, G.; Yaniv, K.; Abdelilah- Seyfried, S.; Fratzl, P.; Masic, A. Simultaneous Raman Microspectroscopy and Fluorescence Imaging of Bone Mineralization in Living Zebrafish Larvae; Elsevier, 2014; Vol. 106.
  67. Narayan, R. J. Monitoring and Evaluation of Biomaterials and their Performance In Vivo; Narayan, R. J., Ed.; Elsevier Ltd: Kidlington, 2017.
  68. Kallepitis, C.; Bergholt, M. S.; Mazo, M. M.; Leonardo, V.; Skaalure, S. C.; Maynard, S. A.; Stevens, M. M. Nat. Commun. 2017, 8, 14843.
  69. Wei, F.; Zhang, D.; Halas, N. J.; Hartgerink, J. D. J. Phys. Chem. B 2008, 112 (30), 9158.
  70. Vera, A. M.; Cárcamo, J. J.; Aliaga, A. E.; Gómez-Jeria, J. S.; Kogan, M. J.; Campos-Vallette, M. M. Spectrochim. Acta Part A Mol. Biomol. Spectrosc. 2015, 134, 251.
  71. Diaz Fleming, G.; Finnerty, J. J.; Campos-Vallette, M.; Célis, F.; Aliaga, A. E.; Fredes, C.; Koch, R. J. Raman Spectrosc. 2009, 40 (6), 632.
  72. Kneipp, K.; Kneipp, H.; Kneipp, J. Acc. Chem. Res. 2006, 39 (7), 443.
  73. Chuang, C.-H.; Chen, Y.-T. J. Raman Spectrosc. 2009, 40 (May 2008), 150.
  74. Aliaga, A. E.; Osorio-Román, I.; Leyton, P.; Garrido, C.; Cárcamo, J.; Caniulef, C.; Celis, F.; Diaz F., G.; Clavijo, E.; Gómez-Jeria, J. S.; Campos-Vallette, M. M. J. Raman Spectrosc. 2009, 40 (2), 164.
  75. Aliaga, A.; Osorio-Roman, I.; Garrido, C.; Leyton, P.; Cárcamo, J.; Clavijo, E.; Gómez-Jeria, J. S.; Díaz, G.; Campos-Vallette, M. M. Vib. Spectrosc. 2009, 50 (1), 131.
  76. Aliaga, A. E.; Garrido, C.; Leyton, P.; Diaz F., G.; Gomez-Jeria, J. S.; Aguayo, T.; Clavijo, E.; Campos-Vallette, M. M.; Sanchez-Cortes, S. Spectrochim. Acta - Part A Mol. Biomol. Spectrosc. 2010, 76 (5), 458.
  77. Cárcamo, J. J.; Aliaga, A. E.; Clavijo, E.; Garrido, C.; Gómez-Jeria, J. S.; Campos-Vallette, M. M. J. Raman Spectrosc. 2012, 43 (6), 750.
  78. Olmedo, I.; Araya, E.; Sanz, F.; Medina, E.; Arbiol, J.; Toledo, P.; Allvarez-Lueje, A.; Giralt, E.; Kogan, M. J. Bioconjug. Chem. 2008, 19 (6), 1154.
  79. Carbone, F. R.; Fox, B. S.; Schwartz, R. H.; Paterson, Y. J. Immunol. 1987, 138 (6), 1838.
  80. Bhayani, H.; Carbone, F. R.; Paterson, Y. J. Immunol. 1988, 141 (2), 377.
  81. Elgueta, R.; Tobar, J. a; Shoji, K. F.; De Calisto, J.; Kalergis, A. M.; Bono, M. R.; Rosemblatt, M.; Sáez, J. C. J. Immunol. 2009, 183 (9), 277.
  82. Garrido, C.; Aliaga, A. E.; Gómez-Jeria, J. S.; Cárcamo, J. J.; Clavijo, E.; Campos-Vallette, M. M. Vib. Spectrosc. 2012, 61, 94.
  83. Aliaga, A. E.; Ahumada, H.; Sepúlveda, K.; Gomez-Jeria, J. S.; Garrido, C.; Weiss-López, B. E.; Campos-Vallette, M. M. J. Phys. Chem. C 2011, 115 (10), 3982.
  84. Garrido, C.; Aliaga, A. E.; Gomez-Jeria, J. S.; Clavijo, R. E.; Campos- Vallette, M. M.; Sanchez-Cortes, S. J. Raman Spectrosc. 2010, 41 (10), 1149.
  86. Lal, S.; Grady, N. K.; Goodrich, G. P.; Halas, N. J. Nano Lett. 2006, 6 (10), 2338.
  87. Cárcamo, J. J.; Aliaga, A. E.; Clavijo, E.; Brañes, M.; Campos-Vallette, M. M. J. Raman Spectrosc. 2012, 43 (2), 248.
  88. Aliaga, A. E.; Aguayo, T.; Garrido, C.; Clavijo, E.; Hevia, E.; Gómez- Jeria, J. S.; Leyton, P.; Campos-Vallette, M. M.; Sanchez-Cortes, S. Biopolymers 2011, 95 (2), 135.
  89. Guerrini, L.; Aliaga, A. E.; Cárcamo, J.; Gómez-Jeria, J. S.; Sanchez- Cortes, S.; Campos-Vallette, M. M.; García-Ramos, J. V. Anal. Chim. Acta 2008, 624 (2), 286.
  90. Leyton, P.; Córdova, I.; Lizama-Vergara, P. A.; Gómez-Jeria, J. S.; Aliaga, A. E.; Campos-Vallette, M. M.; Clavijo, E.; García-Ramos, J. V.; Sánchez-Cortés, S. Vib. Spectrosc. 2008, 46 (2), 77.
  91. Leyton, P.; Domingo, C.; Sanchez-Cortes, S.; Campos-Vallette, M.; Garcia-Ramos, J. V. Langmuir 2005, 21 (25), 11814.
  92. Tąta, A.; Szkudlarek, A.; Kim, Y.; Proniewicz, E. Vib. Spectrosc. 2016, 84, 1.
  93. Święch, D.; Kim, Y.; Proniewicz, E. Vib. Spectrosc. 2016, 83, 101.
  94. Domin, H.; Pieta, E.; Piergies, N.; Swiech, D.; Kim, Y.; Proniewicz, L. M.; Proniewicz, E. J. Colloid Interface Sci. 2015, 437, 111.
  95. Lopez-Tobar, E.; Verebova, V.; Blascakova, L.; Jancura, D.; Fabriciova, G.; Sanchez-Cortes, S. Spectrochim. Acta Part A Mol. Biomol. Spectrosc. 2016, 159, 134.
  96. Lajos, G.; Jancura, D.; Miskovsky, P.; García-Ramos, J. V.; Sanchez- Cortes, S. J. Phys. Chem. C 2008, 112 (33), 12974.
  97. Lopez-Tobar, E.; Antalik, M.; Jancura, D.; Vega, M.; Garc, A.; Fedunova, D.; Fabriciova, G.; Sanchez-Cortes, S. J. Phys. Chem. C 2013, 117, 3996.
  98. Cialla, D.; Pollok, S.; Steinbrücker, C.; Weber, K.; Popp, J. Nanophotonics 2014, 3 (6), 383.
  99. Celis, F.; Campos-Vallette, M. M.; Gómez-Jeria, J. S.; Clavijo, R. E.; Jara, G. P.; Garrido, C. Spectrosc. Lett. 2016, 49 (5), 336.
  100. Pallaoro, A.; Hoonejani, M. R.; Braun, G. B.; Meinhart, C. D.; Moskovits, M. ACS Nano 2015, 4 (4), 4328.
  101. Maiti, K. K.; Samanta, A.; Vendrell, M.; Soh, K.-S.; Olivo, M.; Chang, Y.-T. Chem. Commun. 2011, 47 (12), 3514.
  103. Sharma, B.; Ma, K.; Glucksberg, M. R.; Van Duyne, R. P. J. Am. Chem. Soc. 2013, 135 (46), 17290.
  104. Li, J. F.; Huang, Y. F.; Ding, Y.; Yang, Z. L.; Li, S. B.; Zhou, X. S.; Fan, F. R.; Zhang, W.; Zhou, Z. Y.; Wu, D. Y.; Ren, B.; Wang, Z. L.; Tian, Z. Q. Nature 2010, 464 (7287), 392.
  105. Celis, F.; Campos-Vallette, M.; Cárcamo, J.; Gómez-Jeria, J.; Aliaga, C. J. Chil. Chem. Soc. 2015, 60 (2), 2944.
  106. Zheng, C.; Shao, W.; Paidi, S. K.; Han, B.; Fu, T.; Wu, D.; Bi, L.; Xu, W.; Fan, Z.; Barman, I. Nanoscale 2015, 7 (40), 16960.
  107. Guerrero, A. R.; Aroca, R. F. Angew. Chemie Int. Ed. 2011, 50 (3), 665.
  108. Alarcon, E. I.; Udekwu, K.; Skog, M.; Pacioni, N. L.; Stamplecoskie, K. G.; González-Béjar, M.; Polisetti, N.; Wickham, A.; Richter-Dahlfors, A.; Griffith, M.; Scaiano, J. C. Biomaterials 2012, 33 (19), 4947.
  109. Parnsamut, C.; Brimson, S. Genet. Mol. Res. 2015, 14 (2), 3650.
  110. Khetani, A.; Riordon, J.; Tiwari, V.; Momenpour, A.; Godin, M.; Anis, H. Opt. Express 2013, 21 (10), 12340.
  111. Khetani, A.; Momenpour, A.; Alarcon, E. I.; Anis, H. Biomed. Opt. Express 2015, 23 (22), 8992.
  112. Tiwari, V. S.; Khetani, A.; Momenpour, A.; Anis, H. IEEE J. Sel. Top. Quantum Electron. 2014, 20 (3), 1.
  113. Cui, L.; Mahajan, S.; Cole, R. M.; Soares, B.; Bartlett, P. N.; Baumberg, J. J.; Hayward, I. P.; Ren, B.; Russell, a E.; Tian, Z. Q. Phys. Chem. Chem. Phys. 2009, 11 (7), 1023.
  114. Cui, L.; Wu, D.; Wang, A.; Ren, B.; Tian, Z. J. Phys. Chem. C 2010, 114 (39), 16588.
  115. Ren, B.; Lin, X.-F.; Yang, Z.-L.; Liu, G.-K.; Aroca, R. F.; Mao, B.-W.; Tian, Z.-Q. J. Am. Chem. Soc. 2003, 125 (32), 9598.
  116. Lin, X.-F.; Ren, B.; Yang, Z.-L.; Liu, G.-K.; Tian, Z.-Q. J. Raman Spectrosc. 2005, 36 (6–7), 606.
  117. Tian, Z.-Q.; Yang, Z.-L.; Ren, B.; Wu, D.-Y. In Surface-Enhanced Raman Scattering: Physics and Applications; Kneipp, K., Moskovits, M., Kneipp, H., Eds.; Springer Berlin Heidelberg: Berlin, Heidelberg, 2006; pp 125–146.
  118. Dörfer, T.; Schmitt, M.; Popp, J. J. Raman Spectrosc. 2007, 38 (11), 1379.
  119. Frontiera, R. R.; Henry, A.-I.; Gruenke, N. L.; Van Duyne, R. P. J. Phys. Chem. Lett. 2011, 2 (10), 1199.
  120. Kukura, P.; McCamant, D. W.; Mathies, R. A. Annu. Rev. Phys. Chem. 2007, 58 (1), 461.
  121. Kukura, P.; McCamant, D. W.; Yoon, S.; Wandschneider, D. B.; Mathies, R. A. Science (80-. ). 2005, 310 (5750), 1006.
  122. Fang, C.; Frontiera, R. R.; Tran, R.; Mathies, R. A. Nature 2009, 462 (7270), 200.
  123. Dasgupta, J.; Frontiera, R. R.; Taylor, K. C.; Lagarias, J. C.; Mathies, R. A. Proc. Natl. Acad. Sci. 2009, 106 (6), 1784.
  124. Frontiera, R. R.; Dasgupta, J.; Mathies, R. A. J. Am. Chem. Soc. 2009, 131 (43), 15630.
  125. Laimgruber, S.; Schreier, W. J.; Schrader, T.; Koller, F.; Zinth, W.; Gilch, P. Angew. Chemie Int. Ed. 2005, 44 (48), 7901.
  126. Lockard, J. V.; Butler Ricks, A.; Co, D. T.; Wasielewski, M. R. J. Phys. Chem. Lett. 2010, 1 (1), 215.
  127. Keller, E. L.; Brandt, N. C.; Cassabaum, A. A.; Frontiera, R. R. Analyst 2015, 140 (15), 4922.

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