JOURNAL OF CHILEAN CHEMICAL SOCIETY

Vol 62 No 3 (2017): Journal of the Chilean Chemical Society
Original Research Papers

SECONDARY METABOLITES FROM PACHYSTROMA LONGIFOLIUM (NEES) I. M. JOHNST (EUPHORBIACEAE) AND EVALUATION OF ITS EXTRACTS AS CATHEPSINS INHIBITORS

Dayane de Cássia Galvão
Department of Chemistry, Federal University of Espírito Santo
Carolina Torres Moraes
Department of Chemistry, Federal University of Espírito Santo
Bárbara Juliana Pinheiro Borges
Department of Health Sciences, Federal University of Espírito Santo
Weverson Cavalcante Cardoso
National Museum, Federal University of Rio de Janeiro
Jean Paulo de Andrade
Department of Chemistry, Federal University of Espírito Santo
Pedro Mitsuo Takahashi
Department of Chemistry, Federal University of Espírito Santo
Paulo Cezar Vieira
Department of Chemistry, Federal University of São Carlos
Warley de Souza Borges
Department of Chemistry, Federal University of Espírito Santo
Published September 2, 2017
Keywords
  • Pachystroma longifolium,
  • secondary metabolites,
  • cathepsins
How to Cite
Galvão, D. de C., Torres Moraes, C., Pinheiro Borges, B. J., Cavalcante Cardoso, W., de Andrade, J. P., Mitsuo Takahashi, P., Vieira, P. C., & Borges, W. de S. (2017). SECONDARY METABOLITES FROM PACHYSTROMA LONGIFOLIUM (NEES) I. M. JOHNST (EUPHORBIACEAE) AND EVALUATION OF ITS EXTRACTS AS CATHEPSINS INHIBITORS. Journal of the Chilean Chemical Society, 62(3). Retrieved from https://jcchems.com/index.php/JCCHEMS/article/view/319

Abstract

In this work, four secondary metabolites were isolated from leaves of Pachystroma longifolium (Euphorbiaceae): loliolide, gallic acid, methyl protocatechuate and ethyl gallate. Their structures were established by physical and spectroscopic methods. The extracts of P. longifolium and the purified compounds were tested as cathepsins inhibitors and the extracts were active.

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