JOURNAL OF CHILEAN CHEMICAL SOCIETY

Vol 62 No 3 (2017): Journal of the Chilean Chemical Society
Original Research Papers

CAPTISOL® AS CHIRAL SELECTOR IN CAPILLARY ELECTROPHORESIS OF NON-ACIDIC DRUGS

Monica Budău
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Medicine and Pharmacy
Gabriel Hancu
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Medicine and Pharmacy
Zoltán István Szabó
Department of Pharmaceutical Industry and Pharmaceutical Management, Faculty of Pharmacy, University of Medicine and Pharmacy
Hajnal Kelemen
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Medicine and Pharmacy
Aura Rusu
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Medicine and Pharmacy
Daniela Lucia Muntean
Department of Analytical Chemistry and Drug Analysis, Faculty of Pharmacy, University of Medicine and Pharmacy
Anca Gabriela Cârje
Department of Analytical Chemistry and Drug Analysis, Faculty of Pharmacy, University of Medicine and Pharmacy
Published September 2, 2017
Keywords
  • chiral separation,
  • Captisol®,
  • capillary electrophoresis,
  • cyclodextrines,
  • pharmaceutical analysis
How to Cite
Budău, M., Hancu, G., István Szabó, Z., Kelemen, H., Rusu, A., Muntean, D. L., & Gabriela Cârje, A. (2017). CAPTISOL® AS CHIRAL SELECTOR IN CAPILLARY ELECTROPHORESIS OF NON-ACIDIC DRUGS. Journal of the Chilean Chemical Society, 62(3). Retrieved from https://jcchems.com/index.php/JCCHEMS/article/view/311

Abstract

Enantioseparation of nine extensively used chiral pharmaceutical substances from different pharmacological classes and with different structural characteristics has been investigated by capillary zone electrophoresis using Captisol® (sulfobuthylether-β-cyclodextrin sodium salt) as chiral selector. The influence on the chiral separation of several parameters including pH and concentration of the background electrolyte, chiral selector concentration, applied voltage, system temperature and injection parameters were studied and optimized in order to obtain increased chiral resolution and shorten analysis time. The results were compared with those obtained with native and derivatized neutral cyclodextrins (β-cyclodextrin and hydroxypropryl-β-cyclodextrin). All model molecules were resolved using Captisol® as chiral additive and optimized electrophoretic conditions, proving the efficiency of this anionic derivative of β- cyclodextrin as chiral selector in capillary electrophoresis.

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