Vol 70 No 2 (2025): Journal of The Chilean Chemical Society
Original Research Papers
SYNTHESIS OF NOVEL QUINOLINE DERIVATIVES: A VERSATILE PLATFORM FOR ADVANCED ORGANIC AND MEDICINAL CHEMISTRY
Published
October 6, 2025
Keywords
- heterocyclic compounds,
- organic synthesis,
- quinoline
How to Cite
Castillo-Ríos, D., González-Gutiérrez, I. A., & González Gutiérrez, J. P. (2025). SYNTHESIS OF NOVEL QUINOLINE DERIVATIVES: A VERSATILE PLATFORM FOR ADVANCED ORGANIC AND MEDICINAL CHEMISTRY. Journal of the Chilean Chemical Society, 70(2), 6336-6339. Retrieved from https://jcchems.com/index.php/JCCHEMS/article/view/2802
Copyright (c) 2025 SChQ
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
Abstract
Quinolines are heterocyclic compounds with significant therapeutic potential, initially recognized for their role in treating malaria. Their structural versatility has led to the development of derivatives used in the treatment of various diseases, including Alzheimer's and Parkinson's. Found primarily in plants of the Rutaceae and Rubiaceae families, quinoline derivatives target key enzymes and receptors in the central nervous system. Recent advances focus on enhancing their pharmacokinetic properties to improve efficacy and selectivity in treating neurodegenerative disorders.
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3. Christensen, S. B. Biomedicines. 9, 472 (2021).
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14. Králová, P. & Soural, M. Eur J Med Chem. 269, 116287 (2024).
15. Thawabteh, A. M. et al. Toxins (Basel). 16, 489 (2024).
16. Li, Z., Chen, K., Rose, P. & Zhu, Y. Z. Front Chem. 10, (2022).
17. Elebiju, O. F., Ajani, O. O., Oduselu, G. O., Ogunnupebi, T. A. & Adebiyi, E. Front Chem. 10, (2023).
18. Shal, B., Ding, W., Ali, H., Kim, Y. S. & Khan, S. Front Pharmacol. 9, (2018).
19. Pavlidis, N. et al. J Inorg Biochem. 217, 111393 (2021).
20. Chen, H. et al. J Enzyme Inhib Med Chem. 38, (2023).
21. Ong, W.-Y., Go, M.-L., Wang, D.-Y., Cheah, I. K.-M. & Halliwell, B. Mol Neurobiol. 58, 106–117 (2021).
22. Zhou, W. et al. Drug Discov Today. 25, 2012–2022 (2020).
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25. Szymański, P. et al. Int J Mol Sci. 13, 10067–10090 (2012).
26. Sabandal, P. R., Saldes, E. B. & Han, K.-A. Sci Rep. 12, 20903 (2022).
27. Chen, Z.-R., Huang, J.-B., Yang, S.-L. & Hong, F.-F. Molecules. 27, 1816 (2022).
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29. Hong, S. W., Teesdale-Spittle, P., Page, R. & Truman, P. Neurotoxicology. 93, 163–172 (2022).
30. Waseem, A. M. et al. Results Chem. 13, 101989 (2025).
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