JOURNAL OF CHILEAN CHEMICAL SOCIETY

Vol 66 No 3 (2021): Journal of the Chilean Chemical Society
Original Research Papers

ANTIMICROBIAL AND SOD-LIKE ACTIVITIES OF N,N′-BIS(FERROCENYLMETHYLENE)ETHYLENEDIAMINE SCHIFF BASE AND IT’S METAL COMPLEXES

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  • Funda Demirhan,
  • Hülya Avci Özbek,
  • Tülin Aydemir,
  • Mustafa Oskay,
  • Seda Çinar
Funda Demirhan
Manisa Celal Bayar Universty
Hülya Avci Özbek
Manisa Celal Bayar Universty
Mustafa Oskay
Manisa Celal Bayar Universty
Seda Çinar
Manisa Celal Bayar Universty
Published August 29, 2021
Keywords
  • Antimicrobial activity,
  • Ferrocene,
  • Schiff base,
  • Schiff base metal complex,
  • SOD-like activity
How to Cite
Demirhan, F., Avci Özbek, H., Aydemir, T., Oskay, M., & Çinar, S. (2021). ANTIMICROBIAL AND SOD-LIKE ACTIVITIES OF N,N′-BIS(FERROCENYLMETHYLENE)ETHYLENEDIAMINE SCHIFF BASE AND IT’S METAL COMPLEXES. Journal of the Chilean Chemical Society, 66(3), 5237-5241. Retrieved from https://jcchems.com/index.php/JCCHEMS/article/view/1711

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Abstract

The synthesized N,N′-bis(ferrocenylmethylene)ethylenediamine Schiff base and it’s metal complexes were screened in vitro for antimicrobial activity against two Gram-positive (Staphylococcus aureus ATCC 25923, Bacillus cereus ATCC 7064),four Gram-negative (Escherichia coli ATCC 25922, Citrobacter koseri DBCC 01, Entorebacter aeruginosa ATCC 13048,Salmonella typhimurium DBCC 02) and antifungal activity against a Candida albicans. MIC values of the compounds ranged from 27 to 533 µg/mL. Compound (5) showed very strong activity against S. aureus with the best MIC (27 µg/mL). The lowest MIC for C. albicans was obtained 107 µg/mL. The superoxide dismutase activity of Schiff base and it’s metal complexes has been measured and discussed. SOD-like activities of bis ferrocenyl Schiff base ligand metal complexes were investigated using NBT. While only the Cu (II) complex showed SOD-like (40 μm IC50) activity, the SOD-like activity value was not determined in the other complex and ligand.

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