JOURNAL OF CHILEAN CHEMICAL SOCIETY

Vol 65 No 3 (2020): Journal of the Chilean Chemical Society
Original Research Papers

SYNTHESIS, CHARACTERIZATION AND ANTIBACTERIAL ACTIVITY OF A NEW DERIVATIVE OF LEVOFLOXACIN

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  • Aura Rusu,
  • Silvia Imre,
  • Anca Delia Mare,
  • Ioana-Andreea Lungu,
  • Giorgiana-Andreea Pascu,
  • Valentina Uivarosi
Aura Rusu
Faculty of Pharmacy, George Emil Palade University of Medicine, Pharmacy, Science and Technology of Târgu Mureş, Târgu Mureş, Romania
Bio
Silvia Imre
Faculty of Pharmacy, George Emil Palade University of Medicine, Pharmacy, Science and Technology of Târgu Mureş, Târgu Mureş, Romania
Bio
Anca Delia Mare
Faculty of Medicine, George Emil Palade University of Medicine, Pharmacy, Science and Technology of Târgu Mureş, Târgu Mureş, Romania
Bio
Ioana-Andreea Lungu
George Emil Palade University of Medicine, Pharmacy, Science and Technology of Târgu Mureş, Târgu Mureş, Romania
Bio
Giorgiana-Andreea Pascu
Gedeon Richter Romania
Valentina Uivarosi
Faculty of Pharmacy, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
Bio
Published September 9, 2020
Keywords
  • antibacterial,
  • antibiotic resistance,
  • levofloxacin,
  • silver triflate,
  • triflate
How to Cite
Rusu, A., Imre, S., Mare, A. D., Lungu, I.-A., Pascu, G.-A., & Uivarosi, V. (2020). SYNTHESIS, CHARACTERIZATION AND ANTIBACTERIAL ACTIVITY OF A NEW DERIVATIVE OF LEVOFLOXACIN. Journal of the Chilean Chemical Society, 65(3), 4857-4860. Retrieved from https://jcchems.com/index.php/JCCHEMS/article/view/1489

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Abstract

A new levofloxacin derivative using silver triflate with antibacterial activity was synthesized and characterized. The new compound has been physicochemically characterized through elemental analysis, spectroscopic and thermal methods. All correlated experimental data suggested that the levofloxacin triflate was obtained. The antibacterial activity of the new compound was tested against six Gram-positive and Gram-negative bacteria. In vitro, the new compound had similar activity to levofloxacin against Staphylococcus aureus, Escherichia coli and Klebsiella pneumoniae and very closed to the minimum inhibitory concentration values of levofloxacin against Staphylococcus aureus MRSA, Enterococcus faecalis, and Pseudomonas aeruginosa.

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