JOURNAL OF CHILEAN CHEMICAL SOCIETY

Vol 65 No 3 (2020): Journal of the Chilean Chemical Society
Original Research Papers

SYNTHESIS AND CRYSTAL STRUCTURE ANALYSIS OF A NEW CHALCONE DERIVATIVE OF APOCYNIN

Yanko Moreno
Facultad de Ciencias Básicas, Universidad Santo Tomás, Limonares 190, Viña del Mar, Chile
Bio
Published September 13, 2020
Keywords
  • Apocynin derivative, chalcone, crystal structure.

Abstract

In the present report we present the synthesis and structural analysis of a chalcone derivative of Apocynin, 1-(4-hydroxy-3-methoxyphenyl)-3-(4-nitrophenyl)-2-propenone.

The most characteristic feature of its molecular structure is its near-planarity, allowing molecules to be stacked in columns, at graphite intermolecular distances to each other and connected by a large variety of weak intermolecular interactions.

The molecule presents structural analogies to related ones with significant pharmacological properties (e.g., Apocynin).

imagen2.png

References

  1. References
  2. Robert F Klees 1 , Paul C De Marco, Roman M Salasznyk, Disha Ahuja, Michael Hogg, Sylvain Antoniotti, Lakshmi Kamath, Jonathan S Dordick, George E Plopper
  3. J Biomed Biotechnol, 2, 87246 (2006).
  4. Vogel, S., Barbic, M., JurgenlIemk, G. and Heilmann, J. European Journal of Medicinal Chemistry. 45, 2206-2213 (2010).
  5. Aponte, J. C., Castillo, D., Estevez, Y., Gonzalez, G., Arevalo, J., Hammond, G. B. and Sauvain, M. Chemistry Letters. 20, 100-103, (2010).
  6. Tadigoppula, N., Korthikunta, V., Gupta, S., Kancharla, P., Khaliq, T., Soni, A., Srivastava, R. K., Srivastava, K., Puri, S. K. and Raju, K. S. R. Journal of Medicinal Chemistry. 56, 3145 (2012).
  7. Ameta, K., Kumar, B. and Rathore, N. S. Journal of Chemistry. 8: 665-670 (2011).
  8. Doan, T. N. and Tran, D. T. Pharmacology and Pharmacy. 2: 282-288 (2011).
  9. Syam, S., Abdelwahab, S. I., Al-mamary, M. A. and Mohan, S. Molecules. 17: 6179-6195 (2012).
  10. Asiri, A. M. and Khan, S. A. Molecules. 16: 523-531 (2011).
  11. 9 Nur Izzati Ismail ,Lee Ming-Tatt ,Nordin Lajis ,Muhammad Nadeem Akhtar ,Ahmad Akira ,Enoch Kumar Perimal ,Daud Ahmad Israf andMohd Roslan Sulaiman. Molecules , 21(8), 1077 (2016).
  12. 10 Benso B1, Bustos D2, Zarraga MO3, Gonzalez W4, Caballero J2, Brauchi S5.Int J Biochem Cell Biol. 112,18-23 (2019).
  13. Mark F McCarty, James J DiNicolantonio, and James H O'Keefe . Open Heart. 2(1): e000262 (2015).
  14. Crystallography Reports, volume 62, pages1157–1159(2017)
  15. Sheldrick G.M. ActaCrystallogr. A64 pp. 112–122 (2008).
  16. Sheldrick, G.M. ActaCrystallogr. C71 pp 3–8 (2015).
  17. Spek, A.L. ActaCrystallogr. D65 pp. 148–155 (2009).
  18. Kitaigorodskii, A. I. In Organic Chemical Crystallography. New York: Consultants Bureau (1961).

Copyright @2019 | Designed by: Open Journal Systems Chile Logo Open Journal Systems Chile Support OJS, training, DOI, Indexing, Hosting OJS

Code under GNU license: OJS PKP