JOURNAL OF CHILEAN CHEMICAL SOCIETY

Vol 62 No 1 (2017): Journal of the Chilean Chemical Society
Original Research Papers

EFFECTIVE MICROWAVE SYNTHESIS OF BIOACTIVE THIENO[2,3-d]PYRIMIDINES

Taslimahemad T. Khatri
Department of Chemistry, Lovely Professional University
Viresh H. Shah
Department of Chemistry, KSKV Kachchh University Department of Chemistry, Saurashtra University
Published June 5, 2017
Keywords
  • Gewald reaction,
  • Thieno[2,
  • 3-d]pyrimidines,
  • 3-d]pyrimidin-2(1H)-ones,
  • Antimicrobial activity
How to Cite
Khatri, T. T., & Shah, V. H. (2017). EFFECTIVE MICROWAVE SYNTHESIS OF BIOACTIVE THIENO[2,3-d]PYRIMIDINES. Journal of the Chilean Chemical Society, 62(1). Retrieved from https://jcchems.com/index.php/JCCHEMS/article/view/147

Abstract

A series of novel 2-amino-3-cyanothiophenes (2a-2j) were synthesized using heterogeneous base (K2CO3) supported Gewald reaction. Cyclization of 2a-j with formamide and urea in conventional heating as well as microwave irradiation gave thieno[2,3-d]pyrimidines (3a-3j) and thieno[2,3-d]pyrimidin-2(1H)- ones(4a-4j) respectively. The reaction rates were faster and yields were higher in the microwave conditions. The structures of the compounds were confirmed with elemental analysis, mass spectral analysis, FTIR, 1H NMR and 13C NMR techniques. All the synthesized compounds were subjected to antimicrobial activity (MIC) in vitro by broth dilution method and exhibited a moderate antimicrobial activity. 

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