JOURNAL OF CHILEAN CHEMICAL SOCIETY

Vol 62 No 1 (2017): Journal of the Chilean Chemical Society
Original Research Papers

BENZAMIDE DERIVATIVES AS POTENTIAL CANDIDATES FOR ANTI-ALZHEIMER, ANTI-FATIGUE, ANTI-UREASE AND ANTI-OXIDANT ACTIVITY

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  • M. B. Taj,
  • S. A. Tirmizi,
  • A. Raheel,
  • H. B. M. Ali,
  • S. Qureshi,
  • H. Alshatir
M. B. Taj
Department of Chemistry, Quaid-e-Azam University
S. A. Tirmizi
Department of Chemistry, Quaid-e-Azam University
A. Raheel
Department of Chemistry, Quaid-e-Azam University
H. B. M. Ali
Department of Chemistry, University of Malaya
S. Qureshi
Department of Chemistry, Islamia University
H. Alshatir
Department of Chemistry, Khalias Jeddah University, Jeddah, Saudi Arabia Forensic and Toxicology Department, ElMounfia University, Egypt
Published June 5, 2017
How to Cite
Taj, M. B., Tirmizi, S. A., Raheel, A., Ali, H. B. M., Qureshi, S., & Alshatir, H. (2017). BENZAMIDE DERIVATIVES AS POTENTIAL CANDIDATES FOR ANTI-ALZHEIMER, ANTI-FATIGUE, ANTI-UREASE AND ANTI-OXIDANT ACTIVITY. Journal of the Chilean Chemical Society, 62(1). Retrieved from https://jcchems.com/index.php/JCCHEMS/article/view/144

Copyright (c) 2017 M. B. Taj, S. A. Tirmizi, A. Raheel, H. B. M. Ali, S. Qureshi, H. Alshatir

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Abstract

Benzamide derivatives were screened for their anti-alzheimer, anti-fatigue, anti-urease and anti-oxidant activity and their results were calculated in the form of %age inhibition and IC50 value. Compounds 3a and 3g exhibited the highest anti alzheimer activity. Group of mice’s treated by compounds 3f and 3g showed significantly longer swimming times than those of the treated with caffeine. The prominent urease inhibitory activity was shown by only one compound among seven benzamide derivatives. Controlled experiments suggest that benzamide derivatives (3a-3g) can be serve as the therapeutic agents.

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