Vol 66 No 1 (2021): Journal of the Chilean Chemical Society
Original Research Papers

In-vitro antimicrobial screening and coordination behavior of metals based bidentate compounds

Muhammad Imran
King Khalid University Abha
Published February 9, 2021
  • Bidentate Schiff bases,
  • Metal(II) Complexes,
  • Antibacterial,
  • Antifungal and MIC Activity
How to Cite
Imran, M. (2021). In-vitro antimicrobial screening and coordination behavior of metals based bidentate compounds. Journal of the Chilean Chemical Society, 66(1), 5057-5062. Retrieved from



By condensing ethylene-1,2-diamine with different aldehydes such as benzaldehyde, 4-chloroacetophenone and 2-chlorobenzaldeyhde in 1:2 molar ratio a new Schiff base series (L1)-(L3)  prepared containing bidentate  nitrogen atom. Their metal complexes were synthesized by coordinated the ligand with transition metals as Co(II), Cu(II), Ni(II) and Zn(II). These metal complexes show octahedral geometry. The characterization of the compounds done with the help of spectral, physical and analytical data. Elemental and spectral data of all the ligands and their metal complexes are very consistent with their structure. These show the high purity of these compounds. For in-vitro studies these metal complexes along its ligands were screened against the six bacterial strains; Pseudomonas aeruginosa, Staphylococcus aureus, Escherichia coli, Streptococcus faecalis, Klebsiella pneumoniae and Bacillus subtilis. Six fungal strains; Aspergillus niger, Trichophyton mentogrophytes, Epidermophyton floccosum, Trichophyton schoenleinii, Microscopum canis and Fusarium culmorum were used to study antifungal activity of the compounds. One important indication from their antimicrobial activity was that metal complexes showed high activity than the corresponding ligands. Reason behind the increased activity was chelation process that reduces the polarity of metal ion by complexing with bidentate ligands.


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