JOURNAL OF CHILEAN CHEMICAL SOCIETY

Vol 65 No 1 (2020): Journal of the Chilean Chemical Society
Original Research Papers

ELECTROCHEMICAL DETERMINATION OF N,N-DIMETHYLTRYPTAMINE IN WATER BASED ON TETRARUTHENATED PORPHYRINS AND IONIC LIQUID MODIFIED ELECTRODES

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  • Gonzalo Plaza,
  • Benjamín Piña,
  • Heidy Herrera,
  • Karla Calfuman
Gonzalo Plaza
Escuela de Agronomía, Universidad Mayor
Benjamín Piña
Escuela de Agronomía, Universidad Mayor
Heidy Herrera
Nucleo de Química y Bioquímica, Universidad Mayor.
Karla Calfuman
Facultad de Estudios Interdisciplinarios, Núcleo de Química y Bioquímica, Universidad Mayor, Camino La Piramide #5750, Huechuraba, Chile.
Published February 5, 2020
Keywords
  • Tetraruthenated porphyrins,
  • Modified electrodes,
  • Ionic liquids,
  • DMT
How to Cite
Plaza, G., Piña, B., Herrera, H., & Calfuman, K. (2020). ELECTROCHEMICAL DETERMINATION OF N,N-DIMETHYLTRYPTAMINE IN WATER BASED ON TETRARUTHENATED PORPHYRINS AND IONIC LIQUID MODIFIED ELECTRODES. Journal of the Chilean Chemical Society, 65(1), 4668-4671. Retrieved from https://jcchems.com/index.php/JCCHEMS/article/view/1327

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Abstract

N,N-dimethyltryptamine (DMT) is a short-acting psychotropic agent when administered parenterally and is not active orally due to its rapid degradation by monoamine oxidase enzyme type A. There is growing interest in the therapeutic potential of DMT due to recent clinical data that has shown that produces antidepressant effects in humans. It has also been found that psychedelics that possess the central structure of DMT may have value as medications and cannot simply be labeled as drugs with the potential for abuse.

The incorporation of ionic liquid and tetraruthenated zinc porphyrin to glassy carbon electrode enhanced the voltammetric determination of DMT compared to the bare glassy carbon electrode. These modified electrodes showed good performance for DMT oxidation. These results translate into a low detection limit (1.75 µM), short response time, satisfactory linear concentration range, very good stability and reproducibility. Thus, his methodology can be a feasible and inexpensive way to detect DMT in water and presents potential to be applied in the detection of DMT in urine.

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