JOURNAL OF CHILEAN CHEMICAL SOCIETY

Vol 64 No 1 (2019): Journal of the Chilean Chemical Society
Original Research Papers

A PROMISING DNA GROOVE BINDER AND PHOTOCLEAVER BASED ON A DINUCLEAR RUTHENIUM(II) COMPLEX

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  • Ya-xuan Mi,
  • Shuang Wang,
  • Xue-Xue Xu,
  • Hua-Qian Zhao,
  • Ze-Bao Zheng,
  • Xiao-Long Zhao
Ya-xuan Mi
College of Chemistry & Environmental Science, Hebei University
Shuang Wang
College of Chemistry & Environmental Science, Hebei University
Xue-Xue Xu
College of Chemistry & Environmental Science, Hebei University
Hua-Qian Zhao
College of Chemistry & Environmental Science, Hebei University
Ze-Bao Zheng
College of Chemistry and Chemical Engineering, Taishan University
Xiao-Long Zhao
College of Chemistry & Environmental Science, Hebei University
Published March 27, 2019
Keywords
  • Ruthenium(II) complex,
  • Calf thymus DNA,
  • Groove mode
How to Cite
Mi, Y.- xuan, Wang, S., Xu, X.-X., Zhao, H.-Q., Zheng, Z.-B., & Zhao, X.-L. (2019). A PROMISING DNA GROOVE BINDER AND PHOTOCLEAVER BASED ON A DINUCLEAR RUTHENIUM(II) COMPLEX. Journal of the Chilean Chemical Society, 64(1). Retrieved from https://jcchems.com/index.php/JCCHEMS/article/view/1051

Copyright (c) 2019 Journal of the Chilean Chemical Society

Creative Commons License

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Abstract

A dinuclear ruthenium complex [Ru2(bpy)4(bip-phenol)](ClO4)4 {bpy = 2,2′-bipyridine, bip-phenol = 2,4-bis(1H-imidazo[4,5-f][1,10]phenanthrolin-2-yl) phenol} has been synthesized and characterized. The calf thymus (ct) DNA binding properties of the complex are investigated by means of DNA viscosity and optical spectroscopic techniques of UV-visible absorption and emission spectral titrations, steady-state emission quenching with ferrocyanide, ethidium bromide competitive binding, DNA thermal denaturation and reverse salt effect, together with molecular simulation technology. The results suggest that the complex is a promising DNA groove binder with a large DNA binding constant on 106 M−1 order of magnitude. The fluorescence of the complex manifests by 6.3-fold upon binding saturately to DNA. The complex is also demonstrated to be an efficient photocleaver of pBR 322 DNA.

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