JOURNAL OF CHILEAN CHEMICAL SOCIETY

Vol 67 No 4 (2022): Journal of the Chilean Chemical Society
Original Research Papers

SYNTHESIS AND WOUND HEALING PROPERTIES OF POLYVINYL ALCOHOL FILMS DOPED WITH METAL NANOPARTICLES OF Cu AND Ag

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  • Galo Cárdenas-Triviño,
  • Nelson Linares-Bermudez,
  • Luis Vergara-González,
  • Gerardo Cabello-Guzmán,
  • Javier Ojeda-Oyarzún,
  • Mario Nuñez-Decap,
  • Ramon Arrue-Muñoz
Galo Cárdenas-Triviño
Facultad de Ingeniería, DIMAD, Escuela de Ingeniería Química, Universidad del Bío-Bío, Av. I. Collao 1202, Concepción, Chile and Centro Nacional de Excelencia para la Industria de la Madera CENAMAD, Pontificia Universidad Católica de Chile, Santiago,7820436, Chile
Nelson Linares-Bermudez
Facultad de Ingeniería, DIMAD, Escuela de Ingeniería Química, Universidad del Bío-Bío, Av. I. Collao 1202, Concepción, Chile
Luis Vergara-González
Facultad de Ciencias, Departamento Biología y Química, Universidad San Sebastián, Lientur 1457, Concepción, Chile
Gerardo Cabello-Guzmán
Departamento de Ciencias Básicas, Facultad de Ciencias, Universidad del Bío-Bío, Campus Fernando Mey, Chillán, Chile
Javier Ojeda-Oyarzún
Facultad de Medicina Veterinaria, Universidad Austral de Chile, Independencia 641, Valdivia, Región de los Ríos, Chile
Mario Nuñez-Decap
Facultad de Ingeniería, Departamento de Ingeniería Civil y Ambiental, Universidad del Bío-Bío, Av. I. Collao 1202, Concepción, Chile
Ramon Arrue-Muñoz
Centro Nacional de Excelencia para la Industria de la Madera CENAMAD, Pontificia Universidad Católica de Chile, Santiago,7820436, Chile
Published January 9, 2023
Keywords
  • Antibacterial,
  • biomedical applications,
  • nanoparticles,
  • polyvinyl alcohol,
  • SMAD,
  • wound healing
    • ...More
    Less
How to Cite
Cárdenas-Triviño, G., Linares-Bermudez, N., Vergara-González, L., Cabello-Guzmán, G., Ojeda-Oyarzún, J., Nuñez-Decap, M., & Arrue-Muñoz, R. (2023). SYNTHESIS AND WOUND HEALING PROPERTIES OF POLYVINYL ALCOHOL FILMS DOPED WITH METAL NANOPARTICLES OF Cu AND Ag. Journal of the Chilean Chemical Society, 67(4), 5667-5673. Retrieved from https://jcchems.com/index.php/JCCHEMS/article/view/2136

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Abstract

The skin recovery (wound healing) properties of materials based on polyvinyl alcohol (PVA) doped with metal nanoparticles (PVA-MNPs) and their chemical and physical characterization is reported. The synthesis of copper and silver metal nanoparticles supported in PVA was performed by Solvated Metal Atom Dispersed (SMAD) method using 2-ethoxyethanol as solvent. The average size of metal nanoclusters (PVA-Cu = 77 nm,  PVA-Ag = 72 nm) was determined by TEM and the distribution of the inorganic phase in the hybrid material was analyzed by SEM-EDX. TGA performed in synthetic air atmosphere shows an improvement in the thermal stability by addition of nanometals to pure polymer, with the copper composite showing a higher thermo resistive capacity than the rest. Antibacterial activity against ATCC bacterial strains of Escherichia coli (E.C.), Staphylococcus aureus (S.A.), Staphylococcus epidermidis (S.E.) and Pseudomonas aeruginosa (P.A.) was determined. The silver compound showed antibacterial activity against all tested microorganisms, while the copper compound was active against S.E. Toxicological and wound healing tests were performed in Sprague Dawley rats with infested injuries on the back which were treated with PVA films doped with copper and silver. The recovery of injures infested with S. aureus is reported. This type of material could be used for biomedical applications, such as skin recovery processes in infected wounds or type I and II burns.

 

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